The role of rifaximin in the treatment and chemoprophylaxis of travelers’ diarrhea
نویسندگان
چکیده
Travelers' diarrhea is a common illness among international travelers from developed to developing countries. Travelers' diarrhea is caused by ingestion of contaminated food and water. Bacteria are the primary cause of travelers' diarrhea. In most surveys, the most common diarrheal pathogen identified is enterotoxigenic Escherichia coli. There are several antimicrobial agents available for the treatment of travelers' diarrhea including rifaximin which is approved in the United States for the treatment of travelers' diarrhea due to noninvasive E. coli strains. In this review, we will review the most recent advances of rifaximin for the treatment and prevention of travelers' diarrhea, with regard to its pharmacokinetics, in vitro susceptibility profile, and efficacy and safety data from clinical trials.
منابع مشابه
Effectiveness of rifaximin and fluoroquinolones in preventing travelers’ diarrhea (TD): a systematic review and meta-analysis
BACKGROUND Recent developments related to a safe and effective nonabsorbable antibiotic, rifaximin, and identification of postinfectious irritable bowel syndrome as a frequent sequela call for a need to reconsider the value of primary prevention of traveler's diarrhea (TD) with antibiotics. METHODS Randomized, placebo-controlled, double-blind studies evaluating the effectiveness and safety of...
متن کاملA randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of rifaximin for the prevention of travelers' diarrhea in US military personnel deployed to Incirlik Air Base, Incirlik, Turkey.
BACKGROUND Infectious diarrhea is an important problem among travelers and deployed US military overseas causing substantial morbidity due to acute illness and may result in burdensome postinfectious sequelae. METHODS The nonsystemic antibiotic rifaximin was evaluated for prevention of travelers' diarrhea (TD) in a US military and civilian adult beneficiary population in a randomized, double-...
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TO THE EDITOR—I warmly thank Drs Bradley Connor and Jay Keystone for their meritorious editorial commentary [1] on our research showing that antibiotic use predisposes travelers to colonization with extended-spectrum beta-lactamaseproducing Enterobacteriaceae (ESBL-PE) [2]. They cogitate about fundamental problems associated with refraining from antibiotics for travelers’ diarrhea (TD), listing...
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